Normally, I try to avoid newbie sellers, especially those with a large cache of items. If they lost their main, then where did all the goods come from? Additionally, restock limits prevent newbies from restocking items with higher rarities, so they must have come from another account, stashed there from their main, or some other means.

If the item is something like a paint brush, transmog potion, or something else that is sometimes awarded in random events or as a prize (art gallery, Wheel of ____), or a low rarity (new item) UB, then I make some exceptions on buying.